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Quantifying "just-right" APC inactivation for colorectal cancer initiation
Dysregulation of the tumour suppressor gene Adenomatous Polyposis Coli (APC) is a canonical step in colorectal cancer development. …
Meritxell Brunet Guasch, Nathalie Feeley, Ignacio Soriano, Steve Thorn, Ian Tomlinson, Michael D Nicholson, Tibor Antal
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Strand-resolved mutagenicity of DNA damage and repair
DNA base damage is a major source of oncogenic mutations1. Such damage can produce strand-phased mutation patterns and multiallelic …
Craig J Anderson, Lana Talmane, Juliet Luft, John Connelly, Michael D Nicholson, Jan C. Verburg, Oriol Pich, Susan Campbell, Marco Giasi, Pei-Chi Wei, Vasavi Sundaram, Frances Connor, Takayo Sasaki, David M. Gilbert, Paul A Ginno, Núria López-Bigas, Colin A Semple, Duncan T Odom, Sarah J Aitken, Martin S Taylor
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DNA lesion bypass and the stochastic dynamics of transcription-coupled repair
DNA base damage is a major source of oncogenic mutations and disruption to gene expression. The stalling of RNA polymerase II (RNAP) at …
Michael D Nicholson, Craig J. Anderson, Duncan T. Odom, Sarah J. Aitken, Martin S. Taylor
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Sequential mutations in exponentially growing populations
Author summary In settings such as bacterial infections and cancer, cellular populations grow exponentially. DNA mutations acquired …
Michael D Nicholson, David Cheek, Tibor Antal
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Signatures of TOP1 transcription-associated mutagenesis in cancer and germline
The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by …
Martin A M Reijns, David A Parry, Thomas C Williams, Ferran Nadeu, Rebecca L Hindshaw, Diana O Rios Szwed, Michael D Nicholson, Paula Carroll, Shelagh Boyle, Romina Royo, Alex J Cornish, Hang Xiang, Kate Ridout, Colorectal Cancer Domain UK, 100,000 Genomes Project, Anna Schuh, Konrad Aden, Claire Palles, Elias Campo, Tatjana Stankovic, Martin S Taylor, Andrew P Jackson, The Genomics England Research Consortium, 000 Genomes Project Colorectal Cancer Domain UK 100
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Response to comment on “Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2”
Further analysis of SARS-CoV-2 genome sequencing data identifies several highly recurrent genetic variants with low allele frequencies, …
Michael D Nicholson, Lukas Endler, Alexandra Popa, Jakob-Wendelin Genger, Christoph Bock, Franziska Michor, Andreas Bergthaler
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Breast tumours maintain a reservoir of subclonal diversity during expansion
Our knowledge of copy number evolution during the expansion of primary breast tumours is limited1,2. Here, to investigate this process, …
Darlan C Minussi*, Michael D. Nicholson*, Hanghui Ye*, Alexander Davis, Kaile Wang, Toby Baker, Maxime Tarabichi, Emi Sei, Haowei Du, Mashiat Rabbani, Cheng Peng, Min Hu, Shanshan Bai, Yu-wei Lin, Aislyn Schalck, Asha Multani, Jin Ma, Thomas O McDonald, Anna Casasent, Angelica Barrera, Hui Chen, Bora Lim, Banu Arun, Funda Meric-Bernstam, Peter Van Loo, Franziska Michor, Nicholas E Navin
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Quality and diagnostic performance of coronary computed tomography angiogram (CCTA): A comparison between pre-liver and pre-kidney transplant patients
Purpose Assess and compare the quality and diagnostic performance of CCTA between pre-liver and pre-kidney transplant patients, and …
Rachael R Kirkbride, Emily Larkin, Mark K Tuttle, Michael D Nicholson, Brian G Jiang, Rokas Liubauskas, Jason D Matos, Michael Gavin, Diana E Litmanovich
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Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
Austria was an early hotspot of SARS-CoV-2 transmission due to winter tourism. By integrating viral genomic and phylogenetic analyses …
Alexandra Popa, Jakob-Wendelin Genger, Michael D Nicholson, Thomas Penz, Daniela Schmid, Stephan W Aberle, Benedikt Agerer, Alexander Lercher, Lukas Endler, Henrique Colaço, Mark Smyth, Michael Schuster, Miguel L Grau, Francisco Martínez-Jiménez, Oriol Pich, Wegene Borena, Erich Pawelka, Zsofia Keszei, Martin Senekowitsch, Jan Laine, Judith H Aberle, Monika Redlberger-Fritz, Mario Karolyi, Alexander Zoufaly, Sabine Maritschnik, Martin Borkovec, Peter Hufnagl, Manfred Nairz, Günter Weiss, Michael T Wolfinger, Dorothee von Laer, Giulio Superti-Furga, Núria López-Bigas, Elisabeth Puchhammer-Stöckl, Franz Allerberger, Franziska Michor, Christoph Bock, Andreas Bergthaler
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Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications
Author summary Understanding precisely how some bacteria survive exposure to antibiotics is a major research focus. Specific mutations …
Martín Carballo-Pacheco*, Michael D Nicholson, Elin E Lilja, Rosalind J Allen, Bartlomiej Waclaw
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